Selected Publications


(121) Basu, A.K., Colis, L.C., and Bacurio, J.H.T. (2024)  Mutagenesis and Repair of γ-Radiation- and Radical-Induced Tandem DNA Lesions. DNA 4(2):154-170.

(120) Bacurio, J.H.T.*, Yawson, P.,  Thomforde, J., Zhang, Q., Kumar, H.V., Hartog, H.D., Tretyakova, N.Y., and Basu, A.K. (2024) 5-Formylcytosine mediated DNA-peptide cross-link induces predominantly semi-targeted mutations in both Escherichia coli and human cells. Journal of Biological Chemistry 300(4), 105786.


(119) Bacurio, J.H.T.*, Gao, S.*, Yang, H., Basu, A.K., and Greenberg, M.M. (2023) Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine or Fapy•dG flanked by a 3ʹ 5-formyl-2ʹ-deoxyuridine in human cells. DNA Repair 103527. 

(118) Stanio, S.*, Bacurio, J.H.T.*, Yang, H., Greenberg, M.M., and Basu, A.K. (2023). 8-Oxo-2′-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells Is Less Mutagenic than That of the Corresponding Formamidopyrimidine. Chemical Research in Toxicology 36(5), 782–789.


(117) Basu, A.K., Essigmann, J.M. (2022) Establishing Linkages Among DNA Damage, Mutagenesis, and Genetic Diseases. Chemical Research in Toxicology 35(10), 1655–1675. 

(116) Ryan, B.J., Yang, H., Bacurio, J.H.T., Smith, M.R., Basu, A.K., Greenberg, M.M. and Freudenthal, B.D. (2022) Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication. J. Am. Chem. Soc. 144(18), 8054–8065.


(115) Bacurio, J.H.T., Yang, H., Naldiga, S., Powell, B.V., Ryan, B.J., Freudenthal, B.D., Greenberg, M.M., Basu, A.K., (2021) Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells. DNA Repair 108, 103213.


(114) Powell, B.V., Bacurio, J.H.T., Basu, A.K. (2020) Translesion synthesis of 6-nitrochrysene-derived 2ʹ-deoxyadenosine adduct in human cells. DNA Repair 95, 102935.

(113) Pande, P., Rebello, K.R., Chatterjee, A., Naldiga, S., Basu, A.K. (2020) Site-Specific Incorporation of N-(2′-Deoxyguanosine-8-yl)-6-aminochrysene Adduct in DNA and Its Replication in Human Cells. Chemical Research in Toxicology 33(7), 1997-2005.

(112) Powell, B.P., Basu, A.K. (2020) 6-Nitrochrysene-Derived C8-2′-Deoxyadenosine Adduct: Synthesis of Site-Specific Oligodeoxynucleotides and Mutagenicity in Escherichia coli. Chemical Research in Toxicology. 33(2), 604-613.

(111) Naldiga, S., Huang, H., Greenberg, M.M., Basu, A.K. (2020) Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells. Biochemistry. 59(4), 417-424. 


(110) Naldiga, S., Ji, S., Thomforde, J., Nicolae, C.M., Lee, M., Zhang, Z., Moldovan, G.L., Tretyakova, N.Y., Basu, A.K. (2019) Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells. Journal of Biological Chemistry. 294(27), 10619-10627.


(109) Ji, S., Fu, I., Naldiga, S., Shao, H., Basu, A.K., Broyde, S., Tretyakova, N.Y. (2018) 5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells. Nucleic Acids Research. 46(18), 9892.

(108) Basu, A.K., Nohmi, T. (2018) Chemically-Induced DNA Damage, Mutagenesis, and Cancer. Int. J. Mol. Sci. 19(6), 1767.

(107) Basu, A.K. (2018) DNA Damage, Mutagenesis and Cancer. Int. J. Mol. Sci. 19, 970. 


(106) Basu, A.K., Pande, P., and Bose, A. (2017) Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases. Chem. Res. Toxicol. 30, 61-72.

(105) Pande, P., Ji, S. Sham, Y., Tretyakova, N.Y., and Basu, A.K. (2017) Mutagenicity of a DNA-peptide cross-link in human cells: Roles of TLS polymerases. Chem. Res. Toxicol. 30, 669-677.

(104) Chatterjee, A., Malik, C. K., & Basu, A. K. (2017). Synthesis of oligodeoxynucleotides containing a C8-2′-deoxyguanosine adduct formed by the carcinogen 3-nitrobenzanthrone. Current Protocols in Nucleic Acid Chemistry, 69, 4.73.1–4.73.15.

(103) Mosa, I., Pattammattel, A., Kadimisetty, K., Pande, P., El-Kady, M.F., Bishop, G., Novak, M., Basu, A.K., Kaner, R.B., Kumar, C.V., and Rusling, J.R. (2017) Ultrathin Graphene-Protein Supercapacitors for Miniaturized Bioelectronics. Advanced Energy Materials (in press).


(102) Bose, A., Surugihalli, C., Pande, P., Champeil, E., and Basu, A.K. (2016) Comparative error-free and error-prone translesion synthesis of the N2-2’-deoxyguanosine adducts formed by mitomycin C and its metabolite, 2,7-diaminomitosene, in human cells. Chem. Res. Toxicol. 29, 933–939.

(101) Bose, A., Millsap A.D., DeLeon A., Rizzo, C.J., and Basu, A.K. (2016) Translesion Synthesis of the N2-2′-deoxyguanosine adduct of the dietary mutagen IQ in human cells: Error-free replication by DNA polymerase κ and mutagenic bypass by DNA polymerases η, ζ, and Rev1. Chem. Res. Toxicol. 29, 1549-1559.

(100) Patra, A., Politica, D.A., Chatterjee, A., Tokarsky, E.J., Suo, Z., Basu, A.K., Stone, M.P., and Egli, M. (2016) Mechanism of error free bypass of the environmental carcinogen N-(2′-deoxyguanosin-8-yl)-3-aminobenzanthrone adduct by human DNA polymerase η. ChemBioChem. 17, 1-6.

(99) Tokarsky, E.J., Gadkari, V.V, Zahurancika, W.J., Malik, C.K., Basu, A.K. and Suo, Z. (2016) Pre-Steady-State Kinetic Investigation of Bypass of a Bulky Guanine Lesion by Human Y-family DNA Polymerases. DNA Repair 46, 20-28.


(98) Pande, P., Haraguchi, K., Jiang, Y.-L., Greenberg, M.M., and Basu, A.K. (2015) Unlike Catalyzing Error-Free Bypass of 8-oxodGuo, DNA Polymerase λ Is Responsible for a Significant Part of Fapy•dG-Induced G→T Mutations in Human Cells. Biochemistry 54, 1859-1862. DOI: 10.1021/acs.biochem.5b00119

(97) Pattammattel, A., Williams, C.L., Pande, P., Tsui, W.G., Basu, A.K., and Kumar, C.V. (2015) Biological Relevance of Oxidative Debris Present in As-Prepared Graphene Oxide. RSC Advances, 2015, 5, 59364 -59372.

(96) Bose, A., Pande, P., Jasti, V.P., Hawkins, E.K., Rizzo, C.J., and Basu, A.K. (2015) DNA Polymerase κ and ζ Are Involved in the Mutagenic Translesion Synthesis of the C8-Deoxyguanosine Adduct of the Dietary Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in the NarI Sequence in Human Cells Nucleic Acids Res. 43, 8340-8351.  doi: 10.1093/nar/gkv750.

(95) Vyas, R., Efthimiopoulous, G., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z. (2015) Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Prototype Y-Family DNA Polymerase. J. Am. Chem. Soc. 137, 12131–12142. doi: 10.1021/jacs.5b08027

(94) Weerasooriya, S., Jasti, V.P., Bose, A., Spratt, T.E., and Basu, A.K. (2015) Roles of Translesion Synthesis DNA Polymerases in the Potent Mutagenicity of Tobacco-Specific Nitrosamine-Derived O2-Alkylthymidines in Human Cells. DNA Repair 35, 63-70.

(93) Politica, D.A., Malik, C.K., Basu, A.K., and Stone, M.P. (2015) Base-Displaced Intercalated Structure of the N-(2′-deoxyguanosin-8-yl)-3-aminobenzanthrone DNA Adduct. Chem. Res. Toxicol. 28, 2253-2266.


(92) Pednekar,V., Weerasooriya, S., Jasti, V.P.and Basu, A.K. (2014) Mutagenicity and Genotoxicity of (5’S)-8,5’-Cyclo-2’-Deoxyadenosine in Escherichia coli and Replication of (5’S)-8,5’-Cyclopurine-2’-Deoxynucleosides in vitro by DNA polymerase IV, Exo-free Klenow Fragment and Dpo4. Chem. Res. Toxicol. DOI: 10.1021/tx4002786

(91) Gadkari, V.V., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z. (2014) Mechanistic Investigation of the Bypass of a Bulky Aromatic DNA Adduct Catalyzed by a Y-family DNA Polymerase. DNA Repair 21, 65-77.

(90) Pande, P., Malik, C.K., Bose, A., Jasti, V.P., and Basu, A.K. (2014)   Mutational Analysis of the C8-Guanine Adduct of the Environmental Carcinogen 3-Nitrobenzanthrone in Human Cells: The Critical Roles of DNA Polymerase η, κ, and Rev1 in Error-Prone Translesion Synthesis. Biochemistry 53, 5323-5331.

(89) Weerasooriya, S., Jasti, V.P., and Basu, A.K. (2014) Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences. PLoS One. 9(9): e107915. doi:10.1371/journal.pone.0107915.


(88) Kirouac, K.N., Basu, A.K., and Ling, H. (2013) Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase. Nucleic Acids Res. 41, 2060-2071.

(87) Malik, C.K., Das, R.S., and Basu, A.K. (2013) Synthesis of [1,3, NH215N3] (5’S)-8,5’-cyclo-2’-deoxyguanosine. J. Labelled Compounds and Radiopharmaceuticals 56, 376-381.

(86) Kirouac, K.N., Basu, A.K., and Ling, H. (2013) Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase. J. Mol. Biol. 425, 4167-4176.


(85) Huang, H., Das, R.S., Basu, A.K. and Stone, M.P. (2012) Structure of (5’S)-8,5’-cyclo-2’-deoxyguanosine mismatched with dA or dT. Chem. Res. Toxicol. 25, 478-490.

(84) Sherrer, S.M., Sanman, L.E., Xia, C.X., Bolin, E.R., Malik, C.K., Efthimiopoulos, G., Basu, A.K., and Suo, Z. (2012) Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases. Chem. Res. Toxicol. 25, 730-740.

(83) Sherrer, S.M., Taggart, D.J., Pack, L.R., Malik, C.K., Basu, A.K., and Suo, Z. (2012) Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by human Y-family DNA polymerases. Mutation Research 737, 25-33.

(82) Pande, P., Das, R.S., Sheppard, C., Kow, Y.W., and Basu, A.K. (2012) Repair efficiency of (5’S)-8,5’-cyclo-2’-deoxyguanosine and (5’S)-8,5’-cyclo-2’-deoxyadenosine depends on the complementary base. DNA Repair 11, 926-931.

(81) Das, R.S., Samaraweera, M., Morton, M., Gascón, J.A., and Basu, A.K. (2012) Stability of N-glycosidic bond of (5’S)-8,5’-cyclo-2’-deoxyguanosine. Chem. Res. Toxicol. 25, 2451–2461.


(80) Basu, A.K. (2011) Mutagenesis: The outcome of faulty replication of DNA. Chapter 17 in: “Chemical Carcinogenesis” (Penning, T., ed) Springer, New York. pp 375-400.

(79) Raychaudhury, P. and Basu, A.K. (2011) Genetic requirement for mutagenesis of G[8,5-Me]T cross-link in Escherichia coli: DNA polymerases IV and V compete for error-prone bypass. Biochemistry 50, 2330-2338.

(78) Jasti, V., Das, R.S., Hilton, B.A., Weerasooriya, S., Zou, Y., and Basu, A.K. (2011) (5’S)-8,5’-cyclo-2’-deoxyguanosine is a strong block to replication, potent pol V-dependent mutagenic lesion, and is inefficiently repaired in Escherichia coli. Biochemistry 50, 3862-3865.

(77) Jasti, V., Spratt, T.E., and Basu, A.K. (2011) Tobacco-specific nitrosamine-derived O2-alkylthymidines are potent mutagenic lesions in SOS-induced Escherichia coli. Chem. Res. Toxicol. 24, 1833-1835.

(76) Huang, H., Das, R.S., Basu, A.K. and Stone, M.P. (2011) Structure of (5’S)-8,5’-cyclo-2’-deoxyguanosine in DNA. J. Am. Chem. Soc. 133, 20357-20368.


(75) Brown, K.L., Roginskaya, M., Zou, Y., Altamirano, A., Basu, A.K., and Stone, M.P. (2010) Structural consequences of epimerization of thymine glycol lesions in duplex DNA: Implications for DNA repair. Structural Biology of DNA Damage and Repair, Chapter 2, pp 11-28.  ACS Symposium Series, Volume 1041.

(74) Brown, K.L., Roginskaya, M., Zou, Y., Altamirano, A., Basu, A.K., and Stone, M.P. (2010) Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5′-GTgG-3′ sequence: Destabilization of two base pairs at the lesion site. Nucleic Acids Res. 38, 428 – 440.

(73) Weng, M.-w., Zheng, Y., Jasti, V.P., Champeil, E., Tomasz, M., Wang, Y., Basu, A.K., and Tang, M.-s. (2010) Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Res. 38, 6976-6984.

(72) Raychaudhury, P. and Basu, A.K. (2010) Replication past the γ-radiation-induced guanine-thymine cross-link G[8,5-Me]T by human and yeast DNA polymerase η. Journal of Nucleic Acids Article ID 101495, 10 pages, 2010. doi:10.4061/2010/101495.

(71) Basu, A., Broyde, S., Iwai, S., and Kisker, C. (2010) DNA damage, mutagenesis, and DNA repair (editorial). Journal of Nucleic Acids Article ID 182894, 1 page, 2010. doi:10.4061/2010/182894.