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Our Research

Our research focuses on the initiation phase in the development of cancer. We also study the molecular mechanism of certain anti-cancer drugs that damage DNA. Our goals are to understand the biological outcome of DNA damages caused by nitroaromatic carcinogens, γ-radiation, and the antitumor drug, mitomycin C. Using tools of organic chemistry, chemical biology, molecular biology, and biochemistry, the Basu research team investigates the mechanistic details as to how the differences in organisms, DNA polymerases, and repair proteins may influence the outcome of a lesion in DNA.

Research Overview

Research Overview

Ashis K. Basu

Phone: 860-486-3965
ashis.basu@uconn.edu

Group News

  • New Paper in JACS
    Our work about “Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication” was published in JACS. This is in collaboration with Dr. Freudenthal of the University of Kansas Medical Center and Dr. Greenberg of Johns Hopkins University.
  • ACS Fall 2021: Poster presentation by Henric
    Henric presented a poster with the title “Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells” during the ACS Fall 2021 conference in Atlanta, Georgia (August 2021).
  • New Paper in DNA Repair
    Our work on “Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells” was published in DNA repair. This is in collaboration with Dr. Freudenthal of the University of Kansas Medical Center and Dr. Greenberg of Johns Hopkins University.
  • Congratulations Henric!
    August 2021 – Henric received ACS Division of Chemical Toxicology Graduate Student Travel Award. He received a TOXI travel grant of up to $750 to aid in his attendance and presentation at the ACS 2021 National Meeting which was funded by a grant from the NIH NIEHS, award number R13ES033526.
  • Congratulations Stephen for receiving the 2021 SURF Award!
    Stephen Stanio (MCB, UConn Class of 2022) is one of the 56 undergraduates who received the Summer Undergraduate Research Fund (SURF) award for Summer 2021. The recipients are selected from an exceptionally strong group of applicants representing diverse areas of academic inquiry. Each student will receive a $4,000 stipend as a student researcher and up […]
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